Can I safely quit task demanding activities in the Activity Monitor?

1.) I see that the "Python" often groves very large and is both processor and ram demanding. Why? And it is safe to "kill the python" (quit the process) at any time?
2.) Sometimes I see even two Pythons. Why?
3.) Are there other processor or ram demanding activities I can quit at any time without any trouble?
4.) Are there any ways of avoiding restarts? (I have a great new setup with a program called "Desktop Manager" which is almost like spaces in Osx 10.5 which I would like to keep
5.) It is generally considered "good health" for the Mac to have a restart now and then and Why?
Thanks.

If Python is doing this all the time, then there's a bigger fish to fry. Quitting it isn't a solution. You need to find out what's causing Python to 'hang." When you view the processes in Activity Monitor one of the columns indicates who owns the process - is it you or the system? If it's you then you have something you are using on your computer that requires Python. Look for third-party software you may have installed.
In Activity Monitor double-click on the Python process. A dialog will appear. Click on the Open Files and Ports tab. Scroll through the list to see if anything pops out at you such as another program that is using Python to run some scripts.
You will need to track down whatever is using Python. You should also consider doing some cleanup. Download a utility such as TinkerTool System and use it to clean all user, system, and font caches. If you have a corrupted cache problem this could fix it. You need to do an immediate Restart.

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