Can I use my MacPro on it's side?

I have a need to use my mac pro on it's side for a studio application. Are there any risks involved in this. Obviously the optical drive will not be very useful this way, but for this particular application that will not be an issue.

No issues so long as you place it with the optical drives on the left so the expansion slots are at the bottom and the case opening is on top. Optical drive will work fine sideways as well.

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