Can only open reader once

Whenever I try to open Reader XI or open a .pdf file, it will allow me to open it one time after I start my computer.  If I try to open another .pdf file or even open the first file again (after closing), Adobe Reader will not open. No error messages or anything.  If I reboot my computer, I can access any document again....but again only one document and then subsequent documents will not open.  So only one document per re-boot.  I have deleted and re-installed reader along with all other Adobe products multiple times...nothing helps.  Any help would be appreciated.

"Gump!...you're a G** D**N genius...you're gonna make General!".    It worked.  When I disabled Protected Mode, it said that would also influence "protected view" but after opening several other pdf's, I don think that should be an issue.  Thanks a bunch!

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