Can't access a web/mail server, but all other sites show up fine

Going nuts here. Not sure if this is a network issue, Safari issue, OS issue....
I have an Aiport Extreme going into a cable modem. I have one hard wired iMac and several WiFi devices, including a MacBook Pro and an iPad running off the wireless network. Everything's been fine until...
As of last night, I am unable to pull up my professional web site or check my e-mail. Either the iMac directly connected to the APE (AirPort Extreme) can access it nor can my wireless devices on the wireless network. Every other site I draw up comes up just fine and I can access e-mail on other services (MobileMe for example). I have tried using Safari and FireFox on the Macs to test it also. Connection times out.
I have asked other people to pull up my web site and it comes up for them just fine every time. If I use my iPhone and turn off the wireless netowrk and just go over the 3G, my site and e-mail come in just fine.
I went into the APE and changed a few settings with no change. I then changed the mode from Shared Access to Bridge Mode and success, I was able to access my web site and e-mail again. However, this disables the network and any Internet sharing. Not viable. When I turn on the sharing again, the same problem happens. Right back where I was.
I have tried ordering the router to renew the lease...no joy. I'm at a loss. When I PING my web site address, I get " Request timeout for icmp_seq # ". Any idea what to do?
Thanks.

Just had a thought....was trying to rememberif anything changed last night. I think I installed a mac OS X Security update. That's about the time the trouble started. Any ideas? Thanks.

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