Can't Change IP properties is greyed, Can't Open IE

Hi all,
I've getting a big issue with my application server running windows server 2008 R2.
When trying to change IP the TCP/IP properties remains greyed, Can't open Internet Explorer.And can't run some application as they required administrative rights to write to registry.
I logged in as a domain admin and also as administrator on local and same problem.
I've tried to do a full scan, download malaware and couldn't found any threats.
Any help here please.
Thanks,
Yannick

Could be a UAC issue.
http://windows.microsoft.com/en-us/windows/what-is-user-account-control#1TC=windows-7
you might try with it off to test.
http://windows.microsoft.com/en-us/windows/turn-user-account-control-on-off#1TC=windows-7
Regards, Dave Patrick ....
Microsoft Certified Professional
Microsoft MVP [Windows]
Disclaimer: This posting is provided "AS IS" with no warranties or guarantees , and confers no rights.

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