Can't download any apps anymore.  Get an error of -45054.  Running Yosemite and tried to update itunes, but that doesn't work either.

I "updated" itunes and now I am unable to download any apps.  I receive the error message -45054, try later.  Please advise.

Try repairing disk permissions in Disk Utility (it should be in the Utilities folder in Applications) : https://discussions.apple.com/message/23478840
If that doesn't fix it then try the suggestion three posts further down that thread by the same user (wmark), that appear to have worked for some people

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