Can't install anything since 10.5.3 update

I recently installed the 10.5.3 update on my MacPro (the full package, not just the incremental update from 10.5.2). Yesterday I tried installing the updates Software Update listed, and no go...they'd download and then nothing. For kicks I manually downloaded the Quicktime 7.5 update, and once again no go. I get to the "install" button and nothing happens. I've tried all sorts of installs and it's all the same. I've verified/repaired disk permissions and verified the HD, and everything appears to be checking out fine.
Anybody else experiencing this?

You mentioned you did the full 10.5.3 install. Was that the combo update that you downloaded? If so try installing it again.
Maybe even try installing it from safe boot. So turn the computer on holding down the shift key and then manually installing the 10.5.3 combo update again

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