Can't Open Any Apps: "architecture not supported"

I'm using Snow Leopard on my Intel MBP, but keep handy a clone from a couple years ago on an external hard drive....in case I need to boot from another drive for diagnosis/repair.
The clone on the external is from OS 10.5.7. And whenever I try to launch any apps (including native Mac ones like Safari....which are the versions that were on disk when I cloned) on that drive, I get "can't open; architecture not supported".
I've tried adjusting an app's permissions to let me read/write/own, renaming, and copying the apps.....but they won't open.
Any ideas?
I'll note that I'm trying to launch apps that were cloned at the time I was running OS 10.5.7. I'm not trying to launch apps from my internal drive.

Unless you cloned a working Snow Leopard installation, which unless I'm misunderstanding you did not - you said you cloned 10.5 - then again you probably do not have the Rosetta environment installed. It won't matter that you have 10.5 on the external disk and that the applications are on that drive unless you boot from that drive. Nor will it matter that you cloned a 10.5 drive to your internal when you then upgrade to 10.6; the Rosetta environment does not carry over from 10.5 automatically when you upgrade to 10.6.
Again, try installing Rosetta per the instructions to which I linked.
Regards.

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Can't Open Any Apps: "architecture not supported"

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