Can't open apps. -10810 error

Hey everyone, I have had this issue for about a week now. It seems that if I leave my Mac on for awhile, if I try to launch an app I get a -10810 error and the app wont open. If restart my mac, all is good but then wait a couple of hours and boom, does it again. Also if an app is left running, no problems there. I have done a search in here and in google and can't get an answer. It's only started since 10.5.3 update. I can still work, but if I leave my Mac on, I have to restart it every couple of hours.
It's only happening on my Mac Pro and not my Powerbook and iMac.
Has anyone else had this issue or know what it is or know how to fix it? Thanks in advance.

You can give this a try:
The following have been suggested as possible solutions:
1. Delete the following:
/Library/Caches/com.apple.LaunchServices-0230.csstore
/Library/Caches/com.apple.LaunchServices-023501.csstore
/Home/Library/Preferences/com.apple.LaunchServices.plist
2. If you have Virex or other virus software installed, try uninstalling it. Be sure to use uninstallers that come with the software because simply deleting the application does not fully uninstall most virus software.
After deleting the referenced files above you will want to do a restart. Then use Disk Utility in your Utilities folder to repair permissions.

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