Can't open e-mail link and other problem

I got following problem even one just encountered before sign in.
1. I want to sign in clicked on I already have an account but did not work and have to click on Signin/Register tab any way my main problems.
2. When I get an e-mail and if there is url link even I click it won't open rather return to same page. To open link I have to right click and chose open in new window.
3. On website, if there is a slide show (ex. such as health/food related with photo and text) which need to click Next to read next details, if I click on next it won't work.
4. Recent experience, on Yahoo web there is an online contact form, I have to choose topic/categories/subcategories. I can enter information in one or two fields but next field do not open even I click on them.
What could be the cause of above problems?
Regret to say if I use MS IE 9 I do not face above problems I have tested my self. From MS IE I have moved to Firefox and want to keep using it.

Oops, our posts crossed. The two main changes in Safe Mode would be: (1) disabling Firefox's use of hardware graphics acceleration, and (2) disabling all extensions. You can try to implement those manually in regular mode.
'''(1) Hardware Acceleration'''
Since this feature was added to Firefox, it has gradually improved, but there still are a few glitches with various display drivers.
You usually need to restart Firefox in order for this to take effect, so save all work first (e.g., mail you are composing, online documents you're editing, etc.).
orange Firefox button (or Tools menu) > Options > Advanced
On the "General" mini-tab, uncheck the box for "Use hardware acceleration when available"
If you restart Firefox, are any issues improved? I suggest keeping it disabled even if you do not see an immediate benefit.
'''(2) Extensions'''
Disable ALL nonessential and/or unrecognized extensions. If in doubt, disable:
orange Firefox button (or Tools menu) > Add-ons > Extensions category
Then restart Firefox and test again.

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