Can't Open Files Or Folders By Double Clicking on Its Icon

I'm unable to open any file or folder by double clicking on its icon whether the icon is on my desktop or in a folder.
For example, I can't open my hard disk or any DMG file on desktop by double clicking on its desktop icon, but I can open it or any file or folder by control-clicking on the icon and then clicking on 'open'.
In my Finder, If I double click on an item in 'list' I can open it and in' columns' if I double click on an icon in 'preview' it will open/ launch and in 'cover flow' if I select an icon and double click on it there the file will open/launch.
I've repaired permissions, 'verified disk' in Disk Utility (no problems found),
run Disk Warrior as well as Applejack but the problem persists.... I just can't open by double clicking.
Anyone have any ideas?

Pretty weird...but I think I've heard of it before. I have no direct answer, but when weird stuff like this happens, I think of trying things like:
-boot from OSX DVD and check operation
-Time Machine backup
-Safe Boot - might correct something
-log out of user account and/or log into another user account, and see if doubleclick returns
-and the usual SMC/PRAM reset
I'm assuming you've diddled with the mouse/trackpad settings. Did you try a mouse?

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