Can't open large layered pdf files. Not enough memory

I have a large 300 M layered pdf file that when I attempt to open eventually pops up the "not enough memory (RAM) message.
I am on a windows XP Power Spec computer with 1.97 GB RAM I have allocated 1106 MB for memory useage, 12 history states and 8 cache level.
I have a 187 GB Seagate exterior harddrive as my main scratch disk and a mirrored main drive C with 154 GB of free space as my second scratch disk.
I also experience a canvas disapearance occasionally when using the polygonnal lasso tool. I can be clicking along and all of the sudden the image disapears until I click again. Annoying but not unworkable.
Any ideas?

I can open psd and other file formats of equal size but not pdf's. I switched the scratch discs around to see if that helped but still am getting the same issues

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