Can't open PDF's in MyPDFs or Kindle from within Safari and other problems

When viewing a PDF within Safari, I am unable to execute a "read with" in MyPDFs or Kindle (I don't have iBooks). I have ios 5.  I've also been experiencing delayed keystroke response times and delayed lookups such as for contacts. Keystrokes seem to be off in my touch screen too.
It was intermittent before but now all the time and getting worse.
I have already tried a reset which used to fix all the problems but now doesn't.

have the same problem (click on PDF->opens but is black; left click it->it downloads fine and opens in preview);
machine pb-g4 running 10.4.11
this is the machine of my wife, she says it is happening since a few weeks; not sure what I installed over this period, guess the ->10.4.11, but not sure

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