Can't save file already in use or open

I've seen a lot of posts on this subject, so rather than replying to a specific one that may be on a different trail, I decided to open a new discussion. Lately I've had a lot of problems saving a file while in photoshop cs6 and getting this error. Sure, I can do a save as then delete the former file, but that doesn't solve the problem.  Since it happens so often, I want the solution.  Since the only application I have running when I get this error is Bridge, I closed Bridge when I got this error, and then I could save the file.  In some of the discussion threads on this problem, I did see some reference to previews.  I suspect this has to do with Bridge building previews or extracting previews or something related behind the scenes.  I will keep monitoring this situation to see if closing Bridge always takes care of this problem.  However, I never had this problem before, so I wonder if some of the latest updates created a new problem. I run Windows 7, and all the latest releases of ACR, PS, etc. Thoughts?

Do you have any layered TIFF's?  It was a problem in Bridge as they keep caching.  Do not know if the bug fixed yet. 
Workaround is to turn off TIFF in edit/camera raw in  Bridge.

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