Can't Save File in Excel 2010 Suddenly

I can't save my file all of sudden. These Microsoft updates are causing problems and wasting my time.
Excel 2010
File - xls
Error:
This error occurs when you open a Microsoft Office file type blocked by File Block settings in the Trust Center. To enable this file type, do the following:
Click the File tab.
Under Help, click Options.
Click Trust Center, and then click Trust Center Settings.
In the Trust Center, click File Block Settings.
To save documents with this file type, disable the registry policy setting. For more information, see Microsoft Knowledge Base article 922850.
I folllowed this and allowed everything / unchecked all blocks:
http://support.microsoft.com/kb/945797
+++
Nothing worked. I can't save my file, and I'm late for a meeting. I want a support person to call me. I shouldn't have to pay to fix your bugs.
I've used this file for over a month, and it was working fine until today.

I cannot save, or use excel files, just view them.  I cannot even open up the "file" button in an excel sheet, or use macros or anything that should work.  I shut down my computer this morning, and started it up an hour later, and now the sheet
won't work.  
Is this because of an update microsoft just put out?  If so, how can I disable it?
-Emerald

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