Can't send mail to POP Account which has attachment or signature

Since installing the Update 10.4.6, I have been unable to send email to my pop account which has either a signature or an attachment (when there is no attachment or signature it works fine). I have cleared the caches using tiger cache cleaner. I have tried adding a new user account to mail. It doesn't work in Entourage either. I've reinstalled Mail. What else do you recommend?
Prior to installing the update, mail worked great for over a year!
Additional Information:
Whenever I press the send icon, the mail message disappears, then in the activity viewer it gives the message “Delivering message / Sending data (28% done) and hangs there for a long time and finally gives the following message:
Cannot send message using the server XXX
Use the pop-up menu below to try a different outgoing mail server. All messages will use this server until you quit Mail or change your network settings.
Whenever I send an email with text and a signature, the activity viewer it gives the message “Delivering message / Sending data (100% done) and hangs there for an extremely long time and finally gives the same message.

Mario_MM wrote:
For sending mail the POP server is not important what you need to check are the settings of the SMTP server. Verify the settings of the SMTP server again and compare it to your settings on your iMac.
Checked SMTP settings and they are identical to the working iMac. I had not changed any settings on my MBP when it stopped sending, plus it did work briefly last night with those settings, so I don't see how it could have anything to do with my settings being incorrect.
The only thing even remotely different that I did prior to this happening was to use it away from home. I was out of town and used someone else's wifi to send some emails, but can't see how that should matter. It was the same ISP that I use at home, so I never even had to change settings for remote access. I never touched a thing, but when I got home I could no longer send emails.

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