Can't shut down, some applications don't close and others don't open

I installed Leopard about 3 weeks ago as a clean install not an update. Since then, I have frequent problems shutting down and con only do it manually. I also have some applications - like Firefox - which won't close - the blue light in the dock stays on even after I force quit. Other applications won't open - like Aperture - which seems to get stuck on the serial # screen and never gets further. I have also been getting the dreaded spinning wheel.
I was having this issue on Tiger but I am not sure if it is related to the same problem. It seemed to have something to do with Event Handler...but I am also getting messages similar to one I used to have. "Third Party Client Null - can't create semaphore lock". I am also getting a new message: "Please convert the following to launchd: etc.....
Please help if you can...thanks

By clean install, do you mean "erase and install"? Did you reinstall the problematic progarm ("Event Handler")? If you did reinstall it, do you know if that particular program is Leopard compatible?
Also, what kind of system do you have?

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