Can't start the computer

i shut down the computer last night in a normal way. didn't notice any problem, except my computer run a bit slow when i am surfing in internet. the color wheel appeared from time to time, and i couldn't do anything for a minute.
this morning i wanted to start up the computer, but it stopped at the grey screen with the apple logo and the turning wheel. and that's all. then nothing happened. can anyone give me some advice how to tackle this problem? i checked with the disk utility tool (by starting up with the system DVD and hold pressed C), and the tool said that the harddisk seems to be totally alright.

i've tried the safe mode. first i saw the apple icon and the spinning gear, and then the apple icon changed to a forbidden sign. seems like hopeless. would like very much to know whether there is any chance to get files out of the harddisk. though i backed up with time machine all the time, i've got some problem with the external harddisk so i disconnected it for a few days and get it repaired. didn't back up the documents for the last 5 days. any hope?

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