Can't use any tool that requires 'mouseDown'

Hi,
Using Photoshop CS6 on Win7 64bit on a brand new machine with 'more than average' specs, I seem to be unable to use any tool that requires me to hold my left mouse button. Meaning;
- I can't make selections using any marquee tool
- I can't draw using brushes
- I can't draw shapes (I immediatly get the 'Create rectangle' popup, as if I released my mouse button)
- etc
Furthermore, I can't reverse the zoom direction by holding Alt.
I've reset my preferences to the factory default by deleting Adobe Photoshop X64 CS6 Prefs.psp from the usersettings, this does not seem to solve the problem. I've seen several posts on similar issues, where answers suggest this might be caused by a sticky spacebar; as you can see in this post, this is not the case .
There is an exception to the above; sometimes (not always) I can selections on a fresh start of Photoshop. This ability is lost as soon as I use any other tool.
Does anyone knows a possible cause of this problem? As you might understand, Photoshop is pretty useless this way...
[edit]
As this might arise as a question: it doesn't seem as if another application 'steals focus', as I can always select other tools by using their shortcuts; that would not be possible if PS wouldn't have focus.
[/edit]

Found the issue is even bigger: if I open the marquee menu as shown below by single-right-clicking the marquee tool, I can't left-click any of the shown tools.
(and please don't ask which program I used to create this screenshot cut out; it's not PhotoShop, as I can't make a selection )

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Greg, as you can see from this thread:
http://forums.adobe.com/message/4462265
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Can't use any tool that requires 'mouseDown'

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