Can't write to HD, must reboot, error -50

It's happened four times in three months. Suddenly the Mac can't write to the hard disk (error -50) and I have to reboot. I have to close all open programs with errors because they can't write their configuration files. Recent email mail be lost. I can copy a file from the primary hard disk to another internal hard disk, but I can't duplicate a file on the primary hard disk.

I'm not sure this helps, as the disk is not an iDisk or WebDav, it's just the internal hard disk. Also, I did a Carbon Copy Clone yesterday and it's set to repair permissions before a clone, so permissions were corrected 24 hours before the most recent failure. That said, Disk Utility did report the following issues today:
New permissions:
./Library/ColorSync/Profiles/Displays
./Library/ColorSync/Profiles
./System/Library/Filesystems/cd9660.fs/cd9660.util
New uid:
./private/var/at/jobs.
./private/var/at/spool.
Owner and group corrected on ./private/var/log/install.log
Permissions corrected on ./private/var/log/wtmp

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