Can two different SRM clients systems connect to one R/3 Back-end system?

Hello,
Trying to developing SRM Co-Exist/Global strategy, based on the following scenario:
1.  Two different SRM client systems, each at DIFFERENT SRM Version/Release Level.  SRM system "A" runs in Stand-Alone and Extend Classic Scenario mode.  SRM system "B" runs in Classic Scenario mode
2.  Two different R/3 back-end systems, each with SAME R/3 4.7 Version/Release Level.
Question 1:  Can the two (2) different SRM client systems be connected to one (1) of the R/3 back-end systems?
Question 2:  Are there any Basis Plug-In (PI_BASIS) issues/difficulties to consider from either the SRM client or R/3 back-end side?
Question 3:  Does each SRM client need it own unique transaction document type(s) and number range(s) definitions?
Question 4:  Are there any other difficulties, for example, with RFC and Partner Profile related definitions and what are the steps to address/resolve difficulties?
Please advise and thanks in advance for your feedback!
Regards,
Ed
Edited by: Ed Shigo on Mar 16, 2009 6:40 AM

Question 1: Can the two (2) different SRM client systems be connected to one (1) of the R/3 back-end systems?
They can be connected
Question 2: Are there any Basis Plug-In (PI_BASIS) issues/difficulties to consider from either the SRM client or R/3 back-end side?
Make sure that you have unique consumer entries for Middleware for Material replication, RFCs etc
Question 3: Does each SRM client need it own unique transaction document type(s) and number range(s) definitions?
Yes you need to have them.
Question 4: Are there any other difficulties, for example, with RFC and Partner Profile related definitions and what are the steps to address/resolve difficulties?
Don't see any difficulties as long as the a structured approach is followed.

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