Cannot click on certain area of the screen

I'm not sure if this is a display or a mouse issue. I have had my 24" iMac since June and have just started having this issue. I cannot click (left or right mouse button) on one specific part of the screen. I can click on links and buttons, form boxes, bring up the contextual menu (right click) or do pretty much anything you do with the mouse on most of the screen. However in this approximately half inch high and a few inches long area just above the middle of the screen on the left hand side there is no response from computer when clicking with the mouse. I can click on a link in the browser above this space and below it but not on the link in it. If I move the browser window so that same link appears in a different part of the screen I can click on it fine and cannot click on the link now in the affected area.
This is the same for any clickable item placed in this area of the screen. Is this a display or a mouse issue?

If you have an external drive that can be erased, you could try installing a new system there and setting the Mac to boot from it. That will determine if it is related to the current system installation, or if it is more likely to be a hardware problem. You can obviously also back up your data, erase your internal drive, and reinstall a new system there.
Alternately, as a test, you can just startup from your Mac OS X installation disc. At the first installer screen, go up to the menu bar. Under Utilities, run Disk Utility. Move the Disk Utility window around the screen as needed to see of the same problem exists while booted from a different system. If it happens there, then it is more likely to be some odd hardware-related issue. If it does not, it is possible a fresh system installation will resolve the problem.

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Cannot click on certain area of the screen

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