Cannot click or interact with a certain part of my screen in most apps

This is a weird one that's stumping me. Since probably Tuesday or Wednesday, I've had trouble clicking on certain portions of the screen on my MacBook. I noticed it first in Safari, and I thought that it was just a Safari problem, but now I realize it applies to the whole OS.
When I am in an app, I cannot click on anything or scroll when my mouse is on a certain portion of the screen. The weirdest part to me is that this portion of the screen is standard for every app. It's probably about the middle 50 or 60 percent of my screen in the lower third portion. Imagine cutting my MacBook screen into a Tic-Tac-Toe board... the lower middle box is where I'm having trouble.
This seems to apply to most apps, but for example in iTunes I can still click on items in this portion of the screen but only about every third click will it be responsive. With Safari and Finder and most other apps, I get nothing at all. It's not my mouse itself because it does the same thing if I'm using my Mighty Mouse or my Logitech mouse or just my trackpad. Also, if I navigate using the keyboard, I can interact with that portion of the screen just fine.
I can't recall installing or removing or changing anything significant within the past week that could have caused this, though it's entirely possible. I'm pretty good with my Mac on most things, but as I said, this one is stumping me and I can't find any similar issues by searching.
Thanks in advance for any help.

Got the exact same problem aswell, finally fed up with it now as i just started up firefox and 14 new windows opened because of this bug, luckily my computer can handle them but someone with a slower processor it would have been a nightmare, needs fixing ASAP.
Reverting back to 3.6.3 until this issue is solved. (link for anyone wanting to do the same below)
http://www.filehippo.com/download_firefox/7345/

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This does not happen on my laptop computer or on any other program my work computer runs.

That problem can be caused by the Yahoo! Toolbar or the Babylon extension that extents too much downwards and covers the top part of the browser window and thus makes links and buttons in that part of the screen not clickable.
*https://support.mozilla.org/kb/Troubleshooting+extensions+and+themes
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*Don't make any changes on the Safe mode start window.
*https://support.mozilla.org/kb/Safe+Mode

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iPad, iOS 7.0.4

Try reset iPad
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var images:MovieClip = images_mc;
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I installed 'Mavericks' on my Macbook Pro and am sorry I did !
It wiped my Mac's hard drive totally clean!
A technician here was able to reload the original OS but all my pictures, files and contacts were
sent God knows where !
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Wrong !
He told me that others in our small town had experienced the same problem, and since we live in a small community of about 6000, I wonder how many others have had this problem in more populated centers ?
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Hi All,
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I have a G5 which I intend to keep.
Now that I have updated my iphone 4s to iOS 7.0.
I cannot add music to my iphone or upload photos to iphoto.
I have the last itunes 10.6.3. which was supported by apple.
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Apple made all the equipment I use.
Bentley and Ferrari etc do not stop making parts for their cars?
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Regarding iOS 7.0 you have totally lost the plot.
We buy apple why?
Quality.
Intuitive interface.
Stable software.
Design.
All that Steve Jobs consider sacrosanct.
Quality is about ongoing support longevity of product.
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Glyn Evans
My post on facebook this morning.
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*https://support.mozilla.org/kb/Troubleshooting+extensions+and+themes
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Cannot click or interact with a certain part of my screen in most apps

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