Cannot force quit Mail application or turn off computer

My Mail application has been quite buggy the past few days -- today, it's been at it's worst, and will not allow me to close the application or force shut down on my computer. It very randomly decided to start saving one of my failed messages into my "Recovered Mail" folder multiple times, and now it shows next to my Inbox messages that they were last viewed on "January 1, 1970"
I've tried to force quit Mail and it simply won't close. I need to restart my computer, and even holding down power does nothing... it keeps telling me Mail needs to close first.
I've ran two virus scans and it says nothing is wrong but I'm baffled. Any help or ideas? Thank you

Hi eulojoy,
Some questions about your mail application:
1.) How many email accounts are you checking?
2.) Are they POP, IMAP and/or Exchange?
3.) How many messages do you have in each of those accounts? Hundreds, thousands, tens of thousands?
Did you recently run any OS X updates, such as the one from 10.6.3 to 10.6.4? Has anything changed on your system since the last time Mail worked properly? Do you run any 3rd party plugins for Mail?

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