Cannot initialize Photoshop because preferences file was deleted

Hi. I recently had problems with startup disk being full and had to empty Cache.
Now, when I go to open up Photoshop CS5 for the first time after rebooting, I get this error message:
Cannot initialize Photoshop because preferences file not found, it was deleted.
Can anyone tell me how to correct this problem?
Thank you,
Gail

There is a similar thread HERE with several suggestions.
--OB

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>Yes, many times.
:) never hurts to ask!
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I have the problem where you get the Could not initialize Photoshop because the file is locked, where the solution was to fix the properties in the jpg. I did that and tried the Ctrl-Alt-Shft thing too. I pressed them in time and got the message to delete the settings. When I click yes, I still get the "file locked" message. If it is the scratch disk setting problem, I can't get PS open to change it. This problem started when I was opening a locked jpg from a relative. (Now none of my previous pics will open either). Any other ideas other than these that are already listed in the forums? Thanks for any help.
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Error: "could not initialize photoshop because the file is locked..."

"... user the'properties' command in the Windows Explorer to unlock the file"
Hi,
I've allready read a lot about this, but I can't finde the answer :S
Why can't I find it?
I use Windows 7, all the fixes are for XP or MAC. Ctrl+Alt+Shift won't help. I get the properties menu, not the prompt that asks me to delete/reset some files.
Does anyone know how I can solve this?
== Since when do I get this message? ==
Since 1hour, I pulled out 1gb RAM out of my pc, and inserted 2gb. Now I have 3gb RAM. And now I have the error. I restarted my pc for 4 times and I ran the program as admin.
It works as long as I'm admin, but I don't want to be admin when I'm working with it because that could cause a lot of problems.
I tried if other programs had the same problems but Adobe Fireworks works fine, InDesign and Illustrator works fine too.
Please help!?
Thanks in advance,
Jelmer
====
Creative Suite 3

I allready restarted my pc for 6 times
But with Ctrl+Alt+Shift you reset, you get a prompt popup, wich asks you to reset your prefs. I clicked yes, like you said. The problem is still there
this text is in the message: 'Delte the Adobe Photoshop settings file?' | 'Yes' | 'No'
It's so weird, I added 1gb extra RAM and now it won't work? wtf..? :S
Could it have to do something with my settings?
(Loook @ the Scratch Disks, I have read a lot about that, could it have to do something with that? Adobe Photoshop is installed on in F:\Programs\Adobe CS3\Adobe Photoshop

"could not initialize photoshop because the file could not be found"

I get this error whenever I try and run Photoshop CS3. Any ideas?

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Processor:
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Memory:
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Hard Drive:
156 GB
Video Card:
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Operating System:
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I cannot open photoshop due to file damaged by disc error

I cannot open CS5 due to this message "could not initialize photoshop because the file has been damaged due to disc error

JJ,
I tried everything you mentioned but to no avail, still getting the same response "could not initialize photoshop because the file has been damaged by
disc error. I did run the Chkdsk and it didn't help, I still can't open CS5, not even to check updates....
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Kelli Herring
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Cannot initialize photoshop disk not available.

I have 3 HD's. My Mac OS runs on HD 1 as well as my applications. I use HD 1 & 2 as storage for photos and video. I switched my scratch disc order to HD 2 and HD 3 but clicked off HD 1 as a scratch disk in photoshop extended CS4. Now I cannot open photoshop not even to reset my scratch discs. It will not open because it says it cannot initialize photoshop because disk is unavailable. The weird part is that I cannot open photoshop in CS3 because of the same reason even though I did not touch that. I uninstalled and reinstalled both from disk and time machine but does not help. How do I change back to what I had before I screwed this up. I can't believe the program allows itself to be obstructed so easily without any warning.
Thanks
Scott

Go back in Time Machine to before you did this and restore the Photoshop folders and preferences in the HD\Library\Preferences, HD\Library\Application Support\Adobe, and Home\Library\Preferences folders.
Or you can just dump the preferences and then try to restart PS.
I suggest the Time Machine method in case you have custom workspace settings or paths you don't want to lose and have to reset

CS6 Photoshop reads this when attempting to "Could not initialize Photoshop because the preferences file was invalid (it has been deleted). HELP!

Finally got a call this morning from an Adobe Rep and he explained to me the issue. He explained that I needed to uninstall the adobe product, in this case Photoshop CS6 and download it again and reinstall it! So, I did that and get the same message when attempting to open the newly downloaded software: "Could not initialize Photoshop because the preferences file was invalid (it has been deleted). Please, if someone could help me as soon as possible! I am very anxious to remedy this situation. Thank you!

This seems to have cropped up a lot recently. What has seemed to work so far is intentionally resetting your preferences:
Reset Preferences
1) Close the program and press Ctrl+Alt+Shift (Win)/Cmd+Option+Shift (Mac) during startup (not reversible)
or
2) Move the Folder. See:
http://www.bugge.com/Family-and-friends/Illy/illy.html
--OB

I can't start CS6 I get this error message "Could not initialize Photoshop because the preferences file was invalid (it has been deleted)." What do I do now??

When I try to start CS6 I get this error message "Could not initialize Photoshop because the preferences file was invalid (it has been deleted)." What do I do now??

Please refer:
FAQ: How do I reset my preferences?
Regards,
Ashutosh

After a forced computer shutdown, OS X 10.9.5, I have received this message, PS could not initialize Photoshop because the preference file was invalid (it has been deleted).

After a forced computer shutdown, OS X 10.9.5, I have received this message, PS could not initialize Photoshop because the preference file was invalid (it has been deleted).

One idea is to hold down the cmd-opt-shift keys and start Photoshop. It will ask you if you want to delete the settings file. Answer "Yes" and it will create a new Preferences files. Photoshop should continue to load.
Gene

Cannot initialize Photoshop because preferences file was deleted

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