Cannot Install Itunes 10.2.1 - am at my wits end. Please Please Please Help

Here Goes...
I have just got a new laptop. Nothing special but easily meets the requirements of the Itunes 10.2.1.
Im running Windows 7 (Id have a Mac, but Money constraints took over).
This is my setup:
Laptop HD - Drive C
Portable HD - Drive I
DVD/RW - Drive F
I have used Itunes with my Iphone 3G for some time and to be honest have never had an issue whatsoever.
I have just got this new laptop and have downloaded the Itunes 10.2.1 software from Apple. Previously I ran 10.1.2.17 (I think).
I have double clicked the downloaded file and it takes me through setup. Once it gets to the section where you choose a location for Itunes to install it seems to be defaulted to a location on drive D. I click change location and a dialogue box appears stating invalid location drive D (or words to that effect) It then takes me to the end stating that Itunes cannot be installed.
If I then try and install again it states Invalid location drive D.
This confuses me as I do not have a D drive anyway and I also cannot see why it will not let me change the location to my preference.
Please Help.........
I have tried everything. Cleared the laptop multiple times, re-downloaded Itunes 10.2.1 multiple times. I cant think of anything else.
If this can be sorted and I can get Itunes on the laptop please can someone advise the following.
I plan to keep my Media on the Portable HD as it is 1TB and the laptop is 250GB. Would you advise installing the Itunes to the Laptop HD or the Portable HD.
If I install Itunes on the Laptop and then ask Itunes to find the files on the Portable HD will this just duplicate all of my files so they exist on both harddrives.
Please Help
Thanks
Rich

If I then try and install again it states Invalid location drive D
Try the following user tip with that one:
http://discussions.apple.com/thread.jspa?threadID=2450004

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