Cannot Launch Microsoft or third-party applications!

I am not sure exactly what happened (I think the problem started after some automatic update)...but now I cannot launch Microsoft Office, AIM, or any non-apple applications. I click on the icon on the dock, the icon bounces once, and then nothing happens. I have tried creating new user accounts, and uninstalling and reinstalling the programs, but again, the same thing happens...it will not launch. Is there anything I can do..I'm desperate!
Thanks.

I am having the same problem...and I am pretty sure it happened when I update Office for Mac...because after the update I could not get any office application to start, so I uninstalled then tried to reinstall but was unable to do so. Somehow Zinio also got fouled, and now I can not get/read any of my online magazines. Any help would be very much appreciated! I keep my Mac (17 mbp) completely up to date by running software update weekly, so am not sure that comboupdate will work. Help!?

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