Cannot open any app, doc or message by clicking on their icon?

Any app, doc or message that I try to open by double clicking, either with the mouse or keypad, on the primary icon will not open that item. All that happens is that the icon is highlighted. I then have to open with Command+O or if the item is in the dock it will open by clicking. For example, I can open Safari from the dock but not by clicking on the icon in the Application folder.
I have tried everything that I could to get back to normal…DU from install disk; DU in computer; fsck; reset PRAM; reset PMU: reinstalled 10.4.11 combo and removed various pref files as suggested in this forum. Nothing helps!
The mouse will open & close windows and work online once I manage to get into a program. But I can't open email messages by clicking on them and the same goes for keychain items and there is no Command+O.
Frankly I am mystified. I haven't experienced this before with any of the system or program updates. I would appreciate any help please.

To Apple Discussions!
"and removed various pref files as suggested in this forum."
Was one of them +"com.apple.driver.AppleHIDMouse.plist "+
Have you checked your Mouse settings specifically +Tracking & Double-Click?+
If you are still under the one year warranty and/or have AppleCare contact AC & they will send you another mouse.

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