Cannot print duplex from Preview

When I use my Epson Stylus Photo RX680 to print a document in Pages, I can use the duplex setting to print on both sides of the paper; when I print a document from Preview, the duplex setting is unavailable—grayed out. I've tried opening a PDF in Acrobat Reader, but that has almost no flexibility in print settings, thus no duplex setting.
How can I print a PDF on both sides?

I don't have an Epson RX680 and regrettably am not familiar with that printer, but let me ask you a couple of clarifying questions that, if it doesn't solve your issue outright, will hopefully provide some additional info for other pro bono helpers here to guide their troubleshooting suggestions.
1. In the print dialog box that presents the printer pulldown menu and presets pulldown menu, there is a button to the right of the printer pull-down with either a ▲ or a ▼ symbol. If it is ▼, click on that button to expand the print dialog box to reveal additional print dialog box configuration options.
2. Underneath the newly revealed "Orientation" buttons, there is another pulldown menu that, at least on mine right now, has "Preview" selected. When you activate that pulldown menu, do you have a "Layout" choice? Can you select it or is it grayed out?
3. If you can select that, some additional pull-down menus will be revealed, one of which is "Two-Sided." Choices within there, at least for me, are off, long-edge binding, and short-edge binding. Do you have those options and can you select any of them other than "off" or are those options grayed out?
4. If you can get that far, then you should be able to click on the print button, in order to print duplex from your duplex-capable printer.

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