Cannot receive mail on Exchange 2013 CAS: 451 4.7.0 Temporary server error. Please try again later. PRX4

Hi all,
I have just deployed Exchange 2013 on two CAS boxes and two MBX boxes as follows:
10.10.20.11
CAS01
10.10.20.12
CAS02
10.10.10.11
MBX01
10.10.10.12
MBX02
If I telnet to the internet facing IP on CAS01 and attempt to send an email internally (to a mailbox on MBX01) I get the following:
220 smtp.myrealdomain.com Microsoft ESMTP MAIL Service ready at Wed, 26 Mar 2014 01:14:24 +1000
EHLO test.com
250-smtp.myrealdomain.com Hello [10.10.20.11]
250-SIZE 36700160
250-PIPELINING
250-DSN
250-ENHANCEDSTATUSCODES
250-STARTTLS
250-AUTH
250-8BITMIME
250-BINARYMIME
250 CHUNKING
MAIL FROM:[email protected]
250 2.1.0 Sender OK
RCPT TO:[email protected]
250 2.1.5 Recipient OK
DATA
354 Start mail input; end with <CRLF>.<CRLF>
Subject:Test email 452
This is test email 452
451 4.7.0 Temporary server error. Please try again later. PRX4
Connectivity Log on CAS01:
2014-03-25T15:27:15.353Z,08D11605A575FAE1,SMTP,internalproxy,+,Undefined 00000000-0000-0000-0000-000000000000;QueueLength=<no priority counts>
2014-03-25T15:27:15.353Z,08D11605A575FAE1,SMTP,internalproxy,>,"MBX02.myaddomain.com[10.10.10.12], MBX01.myaddomain.com[10.10.10.11]"
2014-03-25T15:27:15.353Z,08D11605A575FAE1,SMTP,internalproxy,>,Established connection to 10.10.10.12
2014-03-25T15:27:15.369Z,08D11605A575FAE1,SMTP,internalproxy,-,Messages: 0 Bytes: 0 (Attempting next target)
2014-03-25T15:27:15.369Z,08D11605A575FAE2,SMTP,internalproxy,+,Undefined 00000000-0000-0000-0000-000000000000;QueueLength=<no priority counts>
2014-03-25T15:27:15.369Z,08D11605A575FAE2,SMTP,internalproxy,>,Established connection to 10.10.10.11
2014-03-25T15:27:15.369Z,08D11605A575FAE2,SMTP,internalproxy,-,Messages: 0 Bytes: 0 (Retry : EHLO Options do not match for proxy)
2014-03-25T15:28:10.328Z,08D11605A575FAFA,SMTP,internalproxy,+,Undefined 00000000-0000-0000-0000-000000000000;QueueLength=<no priority counts>
2014-03-25T15:28:21.669Z,08D11605A575FAFA,SMTP,internalproxy,>,"MBX01.myaddomain.com[10.10.10.11], MBX02.myaddomain.com[10.10.10.12]"
2014-03-25T15:28:21.669Z,08D11605A575FAFA,SMTP,internalproxy,>,Established connection to 10.10.10.11
2014-03-25T15:28:21.669Z,08D11605A575FAFA,SMTP,internalproxy,-,Messages: 0 Bytes: 0 (Attempting next target)
2014-03-25T15:28:21.669Z,08D11605A575FAFF,SMTP,internalproxy,+,Undefined 00000000-0000-0000-0000-000000000000;QueueLength=<no priority counts>
2014-03-25T15:28:21.669Z,08D11605A575FAFF,SMTP,internalproxy,>,Established connection to 10.10.10.12
2014-03-25T15:28:21.669Z,08D11605A575FAFF,SMTP,internalproxy,-,Messages: 0 Bytes: 0 (Retry : EHLO Options do not match for proxy)
SmtpSend Log on CAS01:
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,1,10.10.20.11:25495,10.10.10.12:25,+,,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,2,10.10.20.11:25495,10.10.10.12:25,<,220 ********************************************************************************************************************,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,3,10.10.20.11:25495,10.10.10.12:25,*,,Proxying inbound session with session id 08D11605A575FB5D
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,4,10.10.20.11:25495,10.10.10.12:25,>,EHLO CAS01.myaddomain.com,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,5,10.10.20.11:25495,10.10.10.12:25,<,250-MBX02.myaddomain.com Hello [10.10.20.11],
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,6,10.10.20.11:25495,10.10.10.12:25,<,250-SIZE,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,7,10.10.20.11:25495,10.10.10.12:25,<,250-PIPELINING,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,8,10.10.20.11:25495,10.10.10.12:25,<,250-DSN,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,9,10.10.20.11:25495,10.10.10.12:25,<,250-ENHANCEDSTATUSCODES,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,10,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXXXXA,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,11,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXXXXXXXXXXB,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,12,10.10.20.11:25495,10.10.10.12:25,<,250-AUTH NTLM,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,13,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXXXXXXXXXXXXXXC,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,14,10.10.20.11:25495,10.10.10.12:25,<,250-8BITMIME,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,15,10.10.20.11:25495,10.10.10.12:25,<,250-BINARYMIME,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,16,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXXXXD,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,17,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXXXE,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,18,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXF,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,19,10.10.20.11:25495,10.10.10.12:25,<,250 XXXXXXXXXXXXXG,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,20,10.10.20.11:25495,10.10.10.12:25,*,,"EHLO options between current server and proxy target do not match : Chunking, Xrdst. Critical non
matching options : Chunking, Xrdst. Failing over."
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,0,,10.10.10.11:25,*,,attempting to connect
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,21,10.10.20.11:25495,10.10.10.12:25,>,QUIT,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,1,10.10.20.11:25496,10.10.10.11:25,+,,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,22,10.10.20.11:25495,10.10.10.12:25,<,221 2.0.0 Service closing transmission channel,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,23,10.10.20.11:25495,10.10.10.12:25,-,,Local
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,2,10.10.20.11:25496,10.10.10.11:25,<,220 ********************************************************************************************************************,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,3,10.10.20.11:25496,10.10.10.11:25,*,,Proxying inbound session with session id 08D11605A575FB5D
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,4,10.10.20.11:25496,10.10.10.11:25,>,EHLO CAS01.myaddomain.com,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,5,10.10.20.11:25496,10.10.10.11:25,<,250-MBX01.myaddomain.com Hello [10.10.20.11],
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,6,10.10.20.11:25496,10.10.10.11:25,<,250-SIZE,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,7,10.10.20.11:25496,10.10.10.11:25,<,250-PIPELINING,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,8,10.10.20.11:25496,10.10.10.11:25,<,250-DSN,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,9,10.10.20.11:25496,10.10.10.11:25,<,250-ENHANCEDSTATUSCODES,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,10,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXXXXA,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,11,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXXXXXXXXXXB,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,12,10.10.20.11:25496,10.10.10.11:25,<,250-AUTH NTLM,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,13,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXXXXXXXXXXXXXXC,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,14,10.10.20.11:25496,10.10.10.11:25,<,250-8BITMIME,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,15,10.10.20.11:25496,10.10.10.11:25,<,250-BINARYMIME,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,16,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXXXXD,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,17,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXXXE,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,18,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXF,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,19,10.10.20.11:25496,10.10.10.11:25,<,250 XXXXXXXXXXXXXG,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,20,10.10.20.11:25496,10.10.10.11:25,*,,"EHLO options between current server and proxy target do not match : Chunking, Xrdst. Critical non
matching options : Chunking, Xrdst. Failing over."
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,21,10.10.20.11:25496,10.10.10.11:25,>,QUIT,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,22,10.10.20.11:25496,10.10.10.11:25,<,221 2.0.0 Service closing transmission channel,
2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,23,10.10.20.11:25496,10.10.10.11:25,-,,Local
Can anyone help? I'm at the end of my Googling!

The answer has been found. In our case, we had to disable the Mailguard feature of the Cisco ASA between the CAS subnet and the MBX subnet. Essentially it was stripping AUTH commands from the SMTP handshake which meant the servers could not authenticate
to each other and establish a secured connection.
I guess for future reference, if you're getting a PRX4 error code you should look at any device that could be inspecting SMTP between your CAS and MBX servers.
This Microsoft KB article has more information: http://support.microsoft.com/kb/320027

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