Cannot run InDesign CS or Photoshop CS after install

I have installed photoshop cs and InDesign CS onto my iMac on Mac OS X 10.3.9. They have installed fully and I have entered the serial numbers in and they have been authorised. The folder then appears in my HD:Applications as normal. However, when I try and open photoshop or image ready it just acts like something is going to happen but nothing does - no response from the computer however long you wait. Why is this happening? Similar thing with InDesign, but it actually starts opening with the main InDesign screen and then unexpectadly quits - every time. Can someone help me on this please.

Hi Craig,
Trey to run Disc Utility --> Disc Repair Permissions
Dimaxum

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Thanks for your response. In the preferences window I have this option;
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and then to check or uncheck...
Auto-acticate fonts for the following applications - the only application listed is Textedit
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Cannot run InDesign CS or Photoshop CS after install

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