Cannot save file because it is open or in use by another program

Windows XP, (or Vista, or Version 7, they all do it) CS2-3 or 4, all combinations have the problem.  Even the Macs.  Today was the worst I've ever seen and I'd love a solutions.
I'm editing in WindowsXP in CS3 and need to send a JPEG version to my client for an approval.
Flatten file, make sure any saved selections are deleted.  Select File / Save As/ and select JPEG instead of PHotoshop.  Select the level of compression..hit OK, and photoshop won't save the file "because it's already open, or another app is using it. 
Try the same thing but wait a while before hitting the final OK (this works more times than not)  not today.
Try changing the filename to Test.jpg Nope
Try changing the filename to A.jpg Nope
Try changing the filename to Test File.jpg Nope
Try saving it as a TIF  That worked. 
Open the tif and try saving THAT as a jpeg.  sometimes it works, somtimes it doesn't.  If it does I can just rename the file. 
Now all of this is going on while my client is looking over my shoulder wondering what sort of booger-eating moron I am.  I'm wondering too of course.
And of course I've got a handful of ~***.psd files that I need to delete.
Now the newest and strangest twist is that when I get home from the office, and connect my removable drive and start the computer, before Windows 7 starts up, the system starts running a chkdks on the drive and scaring the daylights out of me with all of these dire issue it's finding.
Odd that Photoshop will disown a file it just this second created, but at the same time will let you delete a file in Bridge while it is clearly open in Photoshop.
I've seen the same threads for In Design, and Illustrator going all the way back to version 7 (before the CS series)
In my little world it seems high time for a soslutions.  Anyone got any clues they'd be willing to share?

Mr Sullivan...Happens on all three of my systems.
1...Windows XP with CS3 writing to my traveling drive
2...Windows 7 64 bit, CS4 writing to the same drive
3.  Windows XP CS4 writing to an internal laptop drive.
I'm doing a test shot today.  I don't think it will involve the same level of Photoshop dependence that the paying job did, but I'll see what problems persist.  The only change would be a few days rest, and running CHKDSK on the suspicious Drive (which I'll replace this weekend...takes a while to format a large drive and transfer all the contents)
I can't tell you how much I appreciate everyone's ideas.  Thanks thrill seekers.

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