Cannot Start Up Mail

Everytime I start up mail, the mail window comes up as normal but in a second it says its loading (spinning rainbow circle). Then I select the Force Quit option and I find out that my mail is not responding. Any suggestions? I use a MacBook. Thank You.

Verify/repair your disk first (not just permissions), as described here:
The Repair functions of Disk Utility: what's it all about?
Now, go to Apple Menu > System Preferences > Network > Show: Network Port Configurations. Make sure that the configuration used to connect to Internet is at the top of the list. Also, disable any communications/networking configuration enabled, but not in use.
Finally, try launching Mail under the following conditions:
1. Holding the Shift key down until the main window appears.
2. With no Internet connection.
Does any of the above make a difference?
How many accounts do you have and what type are they (POP, IMAP, .Mac)?

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