Cannot update iTunes after motherboard change.

iTunes was on D drive.  After MB change, D drive became E drive.  Updates fails since D drive is now the CD player. 

Define "update". Do you mean Apple Software Update?
The iTunes application normally installs components in Program Files and Program Files (x86) on 64-bit machines. Those folders are normally inside the system drive, which is typically the same as the boot drive. The iTunes library is normally created at <User's Music>/iTunes. If all content has been stored inside the default media folder of .../iTunes/iTunes Media then the library should be portable and can be operated from any path. Hold down shift as you launch iTunes to get an option to choose or create a library, click choose, and browse to the iTunes Library.itl file inside your iTunes folder. Playlists are all stored inside the .itl file. The library consists of the .itl file, some supporting files in the same folder and the album artwork folder, and all media that has attached to the library.
You can't generally save the playlists independently since iTunes records them with absolute paths which may not work if/when you try to reimport. Moving a potable library around as a unit works. See Make a split library portable for background.
tt2

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