CANT FIND FILE OR CORRUPT

I am having more and more trouble opening up files in 4.5.  It used to happen infrequently, now it is happing often, like 5 times today.  When I open the Xcelsius file it will think for some time and then tell me the file is missing or corrupt, then when you click OK, it says excel is busy. Then it gets in the loop.  You have to act like you are opening up another file to get it to stop.  It is beginig to happen on every other file.  Then my CPU will start screaming and it will seize up if I do not shut it down quickly.
What is strange is in the past, I could go to a back up file and recreate.  Today though, I went to same type of template in different folder and even went about 5 weeks back on back up and still get same error.  I know this is not right because one of the files I had backed up last friday and worked on it on tuesday, but it still says that friday run was not good.  The file it says it cannot find just ran in numerical order for the 6 time or so I tried to pulll it up, like im59.xlms.  Something on the like, but the excel files for each template were all save separately, some in different folders.  Does not make since that all files for a particular timeplate would all be corrupt, when saved at differents times and places.
I have downloaded all service paks and hot fixed.
When I try to open in Xcelsius 2008, I get same message.
I have many many templates and many many hours invested, I an now afraid to try to open more, not sure if problem in software is causing this or not.  I hate to invest time to rebuild, as I have the last 3 days because it could happen to them.
I have looked through other strings and the only answer that was close was other instnaces of excel running, but I have look in task manager and no other excel running.
At one time I thought this might be caused by having excel (2007) open first, but I now make sure I open Xcelsius first, no help today.
I have also wondered if it has something to do with moving from a model with old excel to a model with excel 2007 or vice versa????
I have had 4.5 for about 2 years and got 2008 at begining of 2008
Any help would be greatly appreciated I am getting very frustrated.

It seems that 4.5 is somewhat unstable.  After going throught a paid case of tech support for the last 5 days, there is no solution.  It could and most likely will continue to happen.  I am going to migrate to 2008 and import and rework all old models then delete 4.5 in the future.
Sorry for no better news.

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