Cant open Mail application

When I go to open Mail, it won't open and I get the swirling cursor. Does anyone know what to do?
Thanks

Hi oboeguy,
First Quit Mail, then I'd backup these two Mail folders, by right clicking on them in the Finder, then choose Archive/Compress.
Users/YourUserName/Library/Mail
Users/YourUserName/Library/Mail Downloads
(Could be a different folder here if you chose such in Mail Prefs)
Right click on that Mail folder, choose archive, you'll get everything in the folder, and the folder itself in a file called Mail.zip, move it to a safe place, same for the Mail Downloads folder... only the plist is separate.
/Users/YourUserName/Library/Preferences/com.apple.mail.plist
Then Safe Boot from the HD, (holding Shift key down at bootup), run Disk Utility in Applications>Utilities, then highlight your drive, click on Repair Permissions, then move these +folder & file+ to the Desktop.
(Safe boot may stay on the gray radian for a long time, let it go, it's trying to repair the Hard Drive.)
Move this Folder to the Desktop...
/Users/YourUserName/Library/Caches/Mail/
Move this file to the Desktop...
/Users/YourUserName/Library/Mail/Envelope Index
Reboot.

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