Changing preferences in Mail triggers preferences error + certificates

I have recently (within the month) switched to a newer Mac Pro. I didn't use Migration Assistant, but do sync via MobileMe.
Anyway, this suddenly started happening today - As I modify my settings in Mail (Mail>Preferences) and switch panes the following error message pops up:
Writing your preferences to disk has failed. Your preferences may not have been saved. The permissions on ~/Library/Preferences may be wrong or your disk may be full.
I've been using Mail for weeks without any issues (other than the certificate one mentioned below) and I've run repair permissions (without any reported issues) & restarted but I still get the error. My disk has plenty of free space, although I should note that I have a Vista partition because this computer will be added as a render node for a 3D Studio Max machine on our network (my computer is primarily FCP editing/photo retouching).
Also, I'm persistently getting 'Expired Certificate' errors when fetching mail - what's up with that?
Thanks in advance....

These permissions bugs in Lion are pretty prevalent and I've had to reset a lot of application defaults since migrating between machines. Do the following and let me know if it works:
Copy your Mail and Mail Downloads folders in ~/Library/ ( where "~" is referring to your User). Paste these folders your copied into something on your desktop as a back up.
Then navigate to ~/Library/Preferences and find the two .plist files named, "com.apple.mail.plist" and "com.apple.mail.plist.lockedfile" and delete them.
Relaunch Mail.
Relaunching should cause a new .plist file to generate that reads as defualt and using the contents of your ~/Library/Mail folder your OS X Mail shoudl look like it did.
I have issues changing prefs in mail and seem to have a bigger bug at work since I continually have to trash my mail.plist once a week or else I can't connect to my SMTP server. But this always works and I get rid of the, "...writing preferences to your disk has failed..." message.

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