Checklist for eliminating latency?

Using LE8, I've tried everything I know, including increasing the sample rate to 192000, and there is still some slight latency when I use my Yamaha XS8 to play Ivory (stand-alone) piano voices, as opposed to playing the synth's internal voices.....at 44.1 it's completely unplayable. My piano guru/friend runs Ivory at 44.1 samples on a Mac Pro, with no latency whatsoever. Although my Mac isn't a quad core, At 2.8Ghz and 4GB RAM, mine is pretty fast. (I have Ivory sounds on the first partition of a 7,200 RPM Firewire Extreme Lacie, and the software on the Mac.)
Anyway, hints or checklists for all the specific settings I should be looking at would be appreciated. My Interface is the Alesis io|26.

Guitartist wrote:
The Digi CoreAudio Manager is a Digidesign driver that is installed automatically with Pro Tools.
Cool....thanks. I do use Pro Tools for most of my work. I'm wondering if Digi's Core Audio manager has any effect when using Logic....for example does it leave any Buffer setting remnants intact in the Mac system, even when using Logic? I'm having trouble eliminating latency when using Logic -- have tried everything I can find in Logic and Mac settings -- and am wondering if the Core Audio manager is an issue? Thoughts?

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