Cisco ISE Distributed environment question

Hi everyone,
We want to deploy the ISE's nodes in primary- secondary to high availability.
One Node is in Europe and the another node is in America.
Is there exist some restriction about the distance or times, to syncronize between each one?.
Of course, the timezone for each node will be different (GMT - 8 and GMT +1 for example).
I was reading the way for implement it, but it didn't show any information about this.
Regards,

Hi James,
Sorry for answer a little late. I  had not the information before by the client.
The connection between the two sites is a International MPLS (no internet from our perspective). This is the information:
BW: 2 Mbps
Delay: 200 ms
I put the 2 Nodes ISE in that way:
Node in Europe (We will call NodeA):
- Administration (PAN) Primary
- Monitoring (MNT)
- Policy (PSN)
- NTP Server: Public NTP Server. 130.206.3.166
Timezone: UTC
CA Certificate: Self-Certificate_from_ise_node_America
Node in America (We will call NodeB):
- Administration (PAN) Secondary
NTP Server: Public NTP Server. 130.206.3.166 (the same NTP Server)
Timezone: EST
The NodeB is registered from NodeA using its dns name, with no problem (so I assumed that the certificate, credential and DNS resolve correctly).
Waiting for a couple of hour, the NodeB viewed from the NodeA in the section Administration - System - Deployment state OUT OF SYNC.
When I tried to sync manually, the NodeA showed the following message:
Internal Error: Server returned HTTP Response Code: 500 for URL: https://NodeB/deployment-rpc/cert
Expiry status
And happened everytime I tried to sync.
The NodeB is no possible to access through http server web page correctly after its register. It shows the portal page, but it doesn't matter if you use a correct user or bad user, after you click Logging, return a white page without information.
The solution to use the same timezone
I will put in practice, making the nodes using for both UTC.
If you guys have another ideas, it's appreciate it.
Thanks,

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