Clicking on Icon doesn't open Itunes

My Itunes icon isn't opening itunes anymore. I have a MacBook, 10.6.4.1. Thank you!

Hi, tcrboyscout. 
Thank you for visiting Apple Support Communities.
Here are two helpful articles that I would recommend when experiencing issues with iTunes becoming unresponsive.
iTunes: May become unresponsive when connecting iPhone, iPad, or iPod touch
http://support.apple.com/kb/TS3219
iTunes for Windows Vista or Windows 7: Troubleshooting unexpected quits, freezes, or launch issues
http://support.apple.com/kb/ts1717
Apple software on Windows: May see performance issues and blank iTunes Store
http://support.apple.com/kb/TS4123
Cheers,
Jason H.

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