Could not open PS CS6 because disk not available - new info

Running PS CS6 on a Mac Pro, Mt. Lion 10.8.1, 10 GB RAM, 3.6 Tb on 4 internal drives. A new problem cropped up just today.  Launching PS brings error msg Could not open because a dik was not aviable, and a 2nd msg Could not open a scratch file . . . .  Removing Prefs  file works, but there's a BUT: I can't change some prefs without the problem reoccurring.
I can reproduce the following:  reinstall PS CS6, Change 1 preference, namely make another disk the scratch disk, move it to 1st place.  Problem reappears.  It appears I must leave the boot disk as the primary scratch disk.  All my disks are OK, repaired & permissions verified by Disk Util.
Even if I just clear prefs, verify releaunch is OK, and change this one preference, I get the prob.
FWIW here are the last few lines from the Console log:
9/2/12 3:57:12.000 PM kernel[0]: proc 2934: load code signature error 2 for file "Adobe Photoshop CS6"
9/2/12 3:57:12.000 PM kernel[0]: CODE SIGNING: cs_invalid_page(0x100000000): p=2934[Adobe Photoshop ] clearing CS_VALID
9/2/12 3:57:12.000 PM kernel[0]: proc 2936: load code signature error 2 for file "AdobeCrashDaemon"
9/2/12 3:57:13.000 PM kernel[0]: CODE SIGNING: cs_invalid_page(0x100000000): p=2937[sniffer_gpu] clearing CS_VALID
9/2/12 4:00:28.064 PM WindowServer[116]: _CGXGetWindowOrderingGroup: Operation on a window 0x425 requiring rights 0x5 by caller Photoshop

The permissions verification (and repair) functions of Disk Utility will not tell you whether a permissions problem is preventing Photoshop from using your non-boot scratch disk. That only checks to see whether directories and files have permissions which match the permissions that they were given at the time of creation or modification by Apple software installer packages.
My primary "scratch disk" is a non-boot volume. Here are the volume's permissions as seen at the bottom of a Finder Get Info window.

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