"Could not save as 'filename' because of a program error."  Won't allow me to save in ANY format!

I have a large file (3500x8300px) that i have been working on in Photoshop CS4 and i tried to save it after working on it for about 30 minutes and got the following message: "Could not save as 'filename' because of a program error."  I tried saving it as .psd, .pdf, .tif, even .jpg and received the same message each time.  I closed down all other software to ensure that there was enough memory available but to no avail.  I then just closed my MBP and waited until the next day hoping it was just a glitch and might work later on.  I opened it up the next day (forgetting about the save issue) and worked on the file for a few more hours and then tried saving it again. (that's when i remembered the issue...too late...the work was already done).  Nope...still won't let me save it.  I'm afraid i'll have to restart the program but cannot afford to lose this work.  Any thoughts on how to fix it?
*note: i tried 'save for web' and it allowed me to save it as a flattened image (although rather slow due to filesize) but i need it in a layered format.
ANY HELP would be much appreciated!
Thanks.
**(I'm running PS CS4 v. 11.0.2 on a MBP 2.8 GHz Intel Core 2 Duo with 4GB 1067 MHz DDR3 and have Lion OS X 10.7.2.)

There's a long-standing issue in which Windows 7 Explorer sometimes gloms onto image files in the process of caching thumbnails in Thumbs.db files.  Thing is, Windows 7 itself no longer uses these files, because a new thumbnail caching subsystem has been implemented that uses a central database, but the Thumbs.db creation has been maintained by default for compatibility.  The good news is that you can turn it off via the Local System Policy editor, to get some relief from file access conflicts.
Do you have Windows 7?
If ao, and you have no legacy apps that need Thumbs.db files, you can do this:
Click Start, type gpedit.msc into the search box, and hit Enter.
When the Local Group Policy Editor comes up, navigate into:
> User Configuration
> Administrative Templates
> Windows Components
> Windows Explorer
Right-click the entry Turn off the caching of thumbnails in hidden thumbs.db files and choose Edit.
Enable the setting.
Log off Windows and back on.
-Noel

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