Could not save *.* because file is in use or was left open...

OK, I mentioned this when it happened with .eps files, and rather than get a single useful tip(Except for 'choose a new file name'), I got a series of responses from people telling me how I should be saving in .tiff and 'eps files aren't any good anyway, etc., etc... IN other words, no help, just a bunch of opinions on what I was doing wrong in the first place.
Well, now I have had it happen with a .tiff file. I opened the file, did some work, and went to re-save it, and I got the error that it could not save the file because it was in use, or had been left open.
Anybody got any suggestions on why this is happening?
Mac OS 10.4.1
Dual 2.66 GHz Dual core Intel Processors
2 Gb RAM
Photoshop CS3

OOPs I forgot to paste the Adobe help message so here it is;
understand that you receive an error when you try to edit Lightroom
images in Photoshop® CS3.
If you have not already done so, update to Photoshop Lightroom 1.3. In
Photoshop Lightroom, choose Help > Check For Updates. You can also
download the update from the Product Updates page on the Adobe website.
Try specify Photoshop CS3 as the Additional External Editor in your
Lightroom preferences:
- Click the Lightroom menu and choose Preferences.
- Click the External Editing tab.
- Click the Choose button under the Additional External Editor
section.
- Browse to the Photoshop CS3 application file and click Choose. If
Lightroom gives you a warning, select Use Anyway.
- Select an image in the Lightroom Library module, click the Photo
menu and choose the second option for Edit In Adobe Photoshop CS3.
If this does not resolve your issue, it is possible that files from
Photoshop CS2 are interfering with your workflow. To completely remove
Photoshop CS2 files from your computer, follow the instructions in the
following document on our website:
http://kb.adobe.com/selfservice/viewContent.do?externalId=331404
<(>&<)>sliceId=2
If this does not resolve your issue, it is possible that your Lightroom
catalog is damaged. To test the integrity of your catalog:
- Launch Lightroom while holding the Ctrl key on your keyboard.
- Check Test integrity of this catalog
- Click the Select button.
If you have a large number of photos in the catalog, Lightroom may take
some time to complete the testing process and finish launching.
If that does not resolve the issue, quit Lightroom, launch it the same
way and create a new catalog in the Select Catalog window.
If you continue to experience the issue, try the steps in this general
troubleshooting guide on our website:
http://kb.adobe.com/selfservice/viewContent.do?externalId=333653
<(>&<)>sliceId=1

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