Crack in Audio when FireWire LaCie drive plugged

I have a Mac Pro 2.66 with an ATI X1900 XT and 2Gb RAM.
For audio I use the Focusrite Saffire LE (Excellent sound) which is plugged in the FW400 port on the back.
All well so far.
Except that when I plug a LaCie FW 800 hard drive on the front FW800 port, I get crack and pops in audio, with iTunes for example.
And worse, if I copy a file from an internal hard drive to the LaCie, the audio is completely distorted.
When I eject the LaCie drive, and unplug it from the front port, the audio is completely off. No more audio.
I have to restart to get it back.
Is there known problem with FireWire ports in front or back ?

I have the exact same problem. BUt then it got worse: I could only get blips of audio out. After reading your post I went and unplugged the lacie and the audio will play now but I'm still getting pops.
I will be experimenting more.
mac pro dual quad-core   Mac OS X (10.4.9)   16 gig ram

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