CS4 Won't Launch- Red X of Death!

I was using my CS4 this morning.  For unrelated reason, I needed to restart my computer.  I
closed PS CS4, and tried to turn off the machine.  Windows would not shut down
(I had an issue with another program and multiple processes were
lingering from it), so I hit the power button on the
box to force a shut-down.
When Windows restarted, I tried to relaunch CS4.  After the initial splash screen came on, the following error message appeared (next to a scary looking red-silhouetted X):  "Unable to continue because of a hardware or system error.  Sorry, but this error is unrecoverable."  No PS, no nothin'!
I have tried the usual stuff:  Uninstalling and re-installing the software.  I tried the tech guys and was told it was because of me NOT selecting English(US) during the install.  That doesn't make much sense because I wasn't installing it in the first place and one minute it was working the the nex it was not.  Nonetheless, I tried uninstalling AGAIN, and reinstalled watching the language option VERY carefully.  It did not give me a language option, but I noticed it was installing English(US) anyway.  In fact, during the install I saw the installer specifically name the English(US) as the language being installed.
Anyway, I still have the exact same error message.  I was supposed to be preparing a big presentaion today... that is a day lost.  For some reason the phone support is incredibly SLOW today.  I have been on hold now for an hour, with only Muzack to keep me company.
Are there any humans out there???
System Info:
Windows Vista (native) Home Premium
HP A6400f
Intel Dual CPU 2.20GHz
3 GB RAM
32-bit
--Cactus

YOU ARE A GENIUS! 
Resetting the Preferences did the trick.  I wish I had tried this forum HOURS ago!
Actually, I wish the first tech guy I talked to early this afternoon knew what you did.  Jeez!! What a waste of an afternoon.
Thanks SO MUCH!!!!!!!
--Bob

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