CS5 is not responding...any suggestions on what to do

CS5 is not responding...any suggestions on what to do.  The last thing that happened before I stopped responding....
I got a message that Photoshop quit unexpectedly and the next time I tried to open Photoshop it's not responding.  I've tried restarting my computer already. 

Ok, I deleted preferences and then restarted my computer.  Photoshop is still not responding.  When I click to open PS it looks as if it will actually open, but then it gets held up.  The colorwheel shows up here....

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