CS5 on OSX 10.6.8

I don't use Photoshop that often and it had been working fine until today.  It seems that I can Save and Save As..., but if I try to Save For Web I get a write permissions error.  Also, upon closing the program, I get a prompt that my Preferences can't be changed dur to the incorrect file permissions.

So something has changed with the permissions on your system.
Start by checking your preferences folder in ~/Library/Preferences/...

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