CS6 Can't Open/Create Files after a period

I've seen several threads around for a issue the same as this (None with anything useful) and seeing as i can't really see how to explain it, i'll use Coestar's Video:
http://www.youtube.com/watch?v=3Ehx9cFyw7A
Which shows the exact issue i'm having, the only difference is that I'm running CS6 Extended.
The Problem is not always present, sometimes happens on first launch, sometimes after a few hours use.
If it does happen during use ussaly apart from not opening files some tools will act weird like brush strokes going down but disapearing on release of the mouse button...
I've spent the last few days searching the web, these forums and such for a solution but haven't found one...
What i've tried to rectify this:
Reset Preferances
Buying a key and reinstalling... (The issue Appeared on a trial version and hence due to use of the program and the error i bought a key...)
Reinstall Photoshop
Remove Third Party Plugin (Nvidea PS Plugin for Normal maps, ect (The issue started long after this was installed))
Update Nvidea Display Drivers
Update from 13.0 to 13.0.1
Changing to a Larger Scratch disk
resetting Workspace (someone claimed this fixed it for them)
Disabling Anti Virus (Avast!)
Disabling Plug-ins from running on start up (Both through keyboard command and through renaming the plugins folder)
Changing the Default printer
I've contacted the 'Australian' (which actually seemed like a Redirect to another country, but i digress) Customer help desk to no avail, the technical Chat online to which they stated "Come back in 2 hours when the PS team is on" which i'm currently waiting in que for now...
Honestly i doubt anyone i'm contacting on Adobe's side can help, less they be a programmer on the PS team... :/
DxDiag: http://pastie.org/5927099
PS SysInfo: http://pastie.org/5927282#
Message was edited by: Scarecrow398 (Added more details)

Something quite curious just happened, i started without my drivers/utillitys nor steam, started regular programs one by one slowly over time to notice any differnce while doing work and saving every now and then, now at the time i had Teamspeak, Texview 2 (a texture viewer for games), Skype, Nvidea drivers, firefox and adobe updater and CS6 Services.
Now the thing is i was working for around 2 hours with all of this open with no issues, as soon as someone on teamspeak asked me to plug in my headset and talk is buggered out in the time it took to stand up, plug in the headset, sit down, say hi and do a couple of brush strokes, after that i couldn't open a new file, save or use many tools.
My headset is ussaly pluged in most of the time, hence i didn't make hte connection until now when i tried without it.
Unplugging it didn't help at all in solving the issue, it continued on, i assume a restart will probably fix that.
I'm using a Corsair 1500 USB headset and the only keys i hit in photoshop after plugging it in was left click for the brush, shift for a stright stroke and scroll lock (Teamspeak Push to talk key).
I'll do some more checks over the coming day to confim it.

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