Ctrl+S and file save just get ignored and I have to close the file to save docs

I am using DW CS5.5.
Ctrl+S and file>save just get ignored and I have to close the file to save docs.
Any ideas? Thanks

"If this configuration folder is the one in the Program Files hierarchy, you may have shot yourself in the foot.  Never mess with those."
I had a neighbor one time who was annoyed that "that darn bolt on the bottom of my engine" kept scraping on the curb when he'd pull in or out of his driveway, so he ground it down till it was flat with the oil pan. It wasn't till about a year later when he took the car in to have the oil changed that he realized the error of his ways. Cost him $500 to have the pan pulled and replaced.
If you don't know what it does, find out first or leave it alone.

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