Cursor moves around but doesn't open anything

A couple of times my mouse was able to move the cursor, but I wasn't able to open or close programs or show drop-down menus. I turned the computer off to see if that would help. It didn't, but they finally it was ok when I tried again. Is there an easier way (keyboard command) to fix this problem in the future?

Mine started to do that intermittently about one week before the hard drive died. Use your install CD and run the hardware diagnostic.

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